На западе, конечно, положение лучше, но тем не менее, навскидку: 2) Research Misconduct Identified by the US Food and Drug Administration Среди прочего: Fifty-seven published clinical trials were identified for which an FDA inspection of a trial site had found significant evidence of 1 or more of the following problems: falsification or submission of false information, 22 trials (39%); problems with adverse events reporting, 14 trials (25%); protocol violations, 42 trials (74%); и т.д.
3) Fraud and misconduct in clinical research: A concern Fraud and misconduct in clinical research is widespread. Good clinical practice is a guideline adopted internationally as standard operating procedure for conduct of clinical research. Despite these guidelines being available, unavailability of internationally harmonized framework for managing research fraud and misconduct makes clinical research a highly vulnerable area to commit fraud.
4) Data fraud in clinical trials Examples of the first type include a survey of members of the American Association for the Advancement of Science (AAAS) in which 27% of the scientists reported having encountered some type of misconduct [13]; a survey of research coordinators in which 19% of respondents reported first-hand knowledge of misconduct within the previous year – and that only 70% of these were reported [14]; a study of Norway medical investigators in which 27% of investigators knew of instances of fraud [15]; a survey of members of the International Society of Clinical Biostatistics, in which over 50% of respondents knew of fraudulent reports [16]; a survey of medical institutions in Britain in which more than 50% of respondents knew or suspected misconduct among institutional colleagues [17]; and a survey of New Scientist readers, in which a remarkable 92% knew of or suspected scientific misconduct by colleagues [18].
no subject
1) Только на неделе выяснилось, что: 80% of China’s clinical trial data are fraudulent, investigation finds
На западе, конечно, положение лучше, но тем не менее, навскидку:
2) Research Misconduct Identified by the US Food and Drug Administration
Среди прочего: Fifty-seven published clinical trials were identified for which an FDA inspection of a trial site had found significant evidence of 1 or more of the following problems: falsification or submission of false information, 22 trials (39%); problems with adverse events reporting, 14 trials (25%); protocol violations, 42 trials (74%); и т.д.
3) Fraud and misconduct in clinical research: A concern
Fraud and misconduct in clinical research is widespread. Good clinical practice is a guideline adopted internationally as standard operating procedure for conduct of clinical research. Despite these guidelines being available, unavailability of internationally harmonized framework for managing research fraud and misconduct makes clinical research a highly vulnerable area to commit fraud.
4) Data fraud in clinical trials
Examples of the first type include a survey of members of the American Association for the Advancement of Science (AAAS) in which 27% of the scientists reported having encountered some type of misconduct [13]; a survey of research coordinators in which 19% of respondents reported first-hand knowledge of misconduct within the previous year – and that only 70% of these were reported [14]; a study of Norway medical investigators in which 27% of investigators knew of instances of fraud [15]; a survey of members of the International Society of Clinical Biostatistics, in which over 50% of respondents knew of fraudulent reports [16]; a survey of medical institutions in Britain in which more than 50% of respondents knew or suspected misconduct among institutional colleagues [17]; and a survey of New Scientist readers, in which a remarkable 92% knew of or suspected scientific misconduct by colleagues [18].
5) A study in the BMJ last year found that fewer than half the clinical trials financed by the NIH resulted in publication in a scholarly journal within 30 months of completion; a third remained unpublished after 51 months. Only 22% of trials released their summary results within one year of completion, even though the NIH requires that they should.