The reduction was greatest for measles (1,061.1 fold) and smallest for tuberculosis (0.8 fold). The differences in terms of the fold reduction in incidence of the cumulative population varied considerably from 1,295 times for polio to 0.8 times for tuberculosis. With respect to measles, pertussis, and diphtheria, the fold reductions in mortality were higher than the fold reduction in incidence. According to the data in Table 5, the average mortality from pertussis declined by 216 fold in 2006â2015 compared to 1944â1964, but the incidence decreased only by 47 fold, and fatalities due to pertussis decreased by 3.9 fold. If the fold reduction in incidence is divided by the fold reduction in mortality and then multiplied by the fold reduction in lethality, when multiplied by 100%, (i.e., 47/216 · 3.9 · 100%), then the maximum possible contribution of vaccination to the reduction in mortality from pertussis is determined to be 84.9%. This assumes that the risk of infection was constant during the 1944â2015 period.
The case-fatality rate for measles decreased by 95% in 1969 compared to 1944. Obviously, this is due to the radical improvement of material conditions of childrenâs life, advancement of hospital conditions, and superior treatment methods, for example, such as antibiotic treatment of pneumonia and seroprophylaxis. This conclusion is, in part, supported by the observation that a significant reduction in mortality and incidence was observed even before the introduction of vaccination. We believe that the accuracy of our calculations for this type of analysis is quite acceptable for approximate estimation of the immunization contribution to the reduction in mortality, but given the presence of the very large variability of annual epidemiological indicators, the quality of our assessments derives from natural (epidemiological) and logical prerequisites, rather than from the actual reliability of the data used.
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timeasmymeasure
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Date: 2018-10-23 10:14 pm (UTC)Last news from pubmed
https://www.ncbi.nlm.nih.gov/pubmed/30300573
The reduction was greatest for measles (1,061.1 fold) and smallest for tuberculosis (0.8 fold). The differences in terms of the fold reduction in incidence of the cumulative population varied considerably from 1,295 times for polio to 0.8 times for tuberculosis. With respect to measles, pertussis, and diphtheria, the fold reductions in mortality were higher than the fold reduction in incidence. According to the data in Table 5, the average mortality from pertussis declined by 216 fold in 2006â2015 compared to 1944â1964, but the incidence decreased only by 47 fold, and fatalities due to pertussis decreased by 3.9 fold. If the fold reduction in incidence is divided by the fold reduction in mortality and then multiplied by the fold reduction in lethality, when multiplied by 100%, (i.e., 47/216 · 3.9 · 100%), then the maximum possible contribution of vaccination to the reduction in mortality from pertussis is determined to be 84.9%. This assumes that the risk of infection was constant during the 1944â2015 period.
The case-fatality rate for measles decreased by 95% in 1969 compared to 1944. Obviously, this is due to the radical improvement of material conditions of childrenâs life, advancement of hospital conditions, and superior treatment methods, for example, such as antibiotic treatment of pneumonia and seroprophylaxis. This conclusion is, in part, supported by the observation that a significant reduction in mortality and incidence was observed even before the introduction of vaccination. We believe that the accuracy of our calculations for this type of analysis is quite acceptable for approximate estimation of the immunization contribution to the reduction in mortality, but given the presence of the very large variability of annual epidemiological indicators, the quality of our assessments derives from natural (epidemiological) and logical prerequisites, rather than from the actual reliability of the data used.