Our work presents an epidemiological analysis of the dynamics and structure of the annual indicators such as Cumulative Incidence, Mortality Rate (MR), and Case Fatality Rate for infections preventable by vaccines (vaccine-preventable infectionsâVPIs) in Ukraine between 1944 and 2015 compared to the same indicators for infections not preventable by vaccines (nonvaccine-preventable infectionsânon-VPIs). In 1965, the proportion of all infectious diseases in the context of mortality (7.47%), and especially of VPI (3.77%), including those registered among children aged 0â14 years (2.12%), testifies to the low profile of infectious diseases by the time of routine vaccination introduction. Interestingly, in Ukraine between 1965 and 2015, similar rates of mortality reduction were observed in both the total population (1.6â2.6 times) and in children under 14 (15.2â20.4 times) for both VPIs and non-VPIs. During the 1944â2015 period in Ukraine, the reduction of MR of VPI (tuberculosis, diphtheria, tetanus, pertussis, poliomyelitis, measles, and hepatitis B) varied greatly, ranging from 40.5 times (tetanus) to 1,061.1 times (measles), but in general, the reduction incidence rate of VPI was significantly lower ranging from 42.4 times (measles) to 471.1 times (diphtheria). The ratio of incidence and mortality reduction in percent shows the contribution of vaccination to the mortality reduction for various infections during 1944â 2015. This ratio ranged from 0% (tuberculosis) to 84.9% (tetanus), provided that the reduction of the VPI incidence 100% depends on vaccine effects. Thus, we can assume that the observed reduction in mortality for some VPIs was, in part, caused by factors not associated with vaccines.
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timeasmymeasure
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Date: 2018-10-24 07:59 am (UTC)Our work presents an epidemiological analysis of the dynamics and structure of the annual indicators such as
Cumulative Incidence, Mortality Rate (MR), and Case Fatality Rate for infections preventable by vaccines
(vaccine-preventable infectionsâVPIs) in Ukraine between 1944 and 2015 compared to the same indicators for
infections not preventable by vaccines (nonvaccine-preventable infectionsânon-VPIs). In 1965, the proportion
of all infectious diseases in the context of mortality (7.47%), and especially of VPI (3.77%), including those
registered among children aged 0â14 years (2.12%), testifies to the low profile of infectious diseases by the time
of routine vaccination introduction. Interestingly, in Ukraine between 1965 and 2015, similar rates of mortality reduction
were observed in both the total population (1.6â2.6 times) and in children under 14 (15.2â20.4 times) for both
VPIs and non-VPIs. During the 1944â2015 period in Ukraine, the reduction of MR of VPI (tuberculosis,
diphtheria, tetanus, pertussis, poliomyelitis, measles, and hepatitis B) varied greatly, ranging from 40.5 times
(tetanus) to 1,061.1 times (measles), but in general, the reduction incidence rate of VPI was significantly lower
ranging from 42.4 times (measles) to 471.1 times (diphtheria). The ratio of incidence and mortality reduction in
percent shows the contribution of vaccination to the mortality reduction for various infections during 1944â
2015. This ratio ranged from 0% (tuberculosis) to 84.9% (tetanus), provided that the reduction of the VPI
incidence 100% depends on vaccine effects. Thus, we can assume that the observed reduction in mortality for
some VPIs was, in part, caused by factors not associated with vaccines.
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