Есть куча исследований о двукратной дозе в 200,000 МЕ в случае кори, и нигде там не написано о побочных эфектах. Здесь пишут про токсичность высоких доз у детей не больных корью: "In young children, 100,000 IU (30 mg) of vitamin A at 6–11 mo and 200,000 IU (60 mg) every 3 to 6 mo for children aged 12–60 mo, gives few side effects and is effective for reducing mortality (15). In 1980 a 300,000-IU dose—a higher level than is now recommended—produced a 6% incidence of vomiting and a 16% incidence of transient diarrhea in Indonesian preschoolers (16). Doses of 100,000 and 200,000 IU caused nausea, vomiting, headache, diarrhea and fever among some children in the Philippines (17). The incidence of these symptoms was higher with the larger of the two doses and among the smallest children during the first 2 y of life. Thus, transient nausea and vomiting are expected in 5–10% of the youngest children receiving these doses (3)."
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timeasmymeasure
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Date: 2018-01-25 09:54 am (UTC)Здесь пишут про токсичность высоких доз у детей не больных корью:
"In young children, 100,000 IU (30 mg) of vitamin A at 6–11 mo and 200,000 IU (60 mg) every 3 to 6 mo for children aged 12–60 mo, gives few side effects and is effective for reducing mortality (15). In 1980 a 300,000-IU dose—a higher level than is now recommended—produced a 6% incidence of vomiting and a 16% incidence of transient diarrhea in Indonesian preschoolers (16). Doses of 100,000 and 200,000 IU caused nausea, vomiting, headache, diarrhea and fever among some children in the Philippines (17). The incidence of these symptoms was higher with the larger of the two doses and among the smallest children during the first 2 y of life. Thus, transient nausea and vomiting are expected in 5–10% of the youngest children receiving these doses (3)."